What goes wrong with The Pre-Menstrual-Syndrome?

WHAT GOES WRONG?THE PRE-MENSTRUAL-SYNDROME

There are many factors which suggest that progesterone definciency is the cause of the pre-menstrual-syndrome. For instance:

1. The symptoms are only present when progesterone should be present in the blood stream, ie. after ovulation up to menstruation. The symptoms disappear when progesterone is absent from the blood- stream ie. after menstruation.2. The onset is usually either at puberty, after a pregnancy, after pill-taking, or when menstruation returns after a long absence: all times of hormonal upset.3. There is a frequent absence of symptoms during pregnancy when high amounts of progesterone are produced by the placenta.4. Temperature charts confirm that the rise after ovulation is poorly sustained in sufferers of the pre-menstrual-syndrome.5. The average progesterone level after ovulation is lower in sufferers of the pre-menstrual-syndrome than in normal women without menstrual symptoms.

Merely to say that there is a progesterone deficiency still leaves many questions waiting for an answer. For example:

a. Is there insufficient production of progesterone from the ovary?

b. Is there insufficient luteinising hormone (LH) produced by the pituitary gland?

c. Is there insufficient luteinising hormone releasing hormone(LHRH) produced by the hypothalamus

d. Is the progesterone deficiency a true deficiency or merely in comparison to the high oestrogen so often found in sufferers of the syndrome?

e. Is the progesterone feedback pathway being blocked by too high a level of prolactin produced by the pituitary gland?

It is probable that cases of the pre-menstrual-syndrome fall into one or more of these groups, but up to now we have not been able to differentiate these factors.

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